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Author Archives: Adrian Marino-Enriquez
Biphenotypic sinonasal sarcoma with PAX3-FOXO1 fusion gene! (?)
In our most recent publication in Genes, Chromosomes and Cancer, Alexandra and Waihay have characterized an interesting biphenotypic sinonasal sarcoma with a PAX3-FOXO1 fusion gene. We found the PAX3-FOXO1 genetic fusion characteristic of a highly aggressive, lethal sarcoma (alveolar rhabdomyosarcoma) driving a locally-aggressive, but essentially non-metastatic tumor; how’s that for cellular/genetic context and tumor microenvironment modulating oncogenic events? Our modest case report contributes to an increasing understanding of the genetics of biphenotypic sinonasal sarcoma, and raises interesting biological questions that are also being explored by colleagues from Mayo Clinic and MSKCC in larger case series.
New publication in Molecular Cancer Therapeutics!
Our DFSP work, characterizing CDK4 as a therapeutic target in imatinib-resistant DFSP and introducing the first patient-derived representative model of FS-DFSP, has been published in the AACR journal Molecular Cancer Therapeutics. Check it out here.
DFSP poster presented at AACR 2015 annual meeting
It was great presenting some of our group’s work on dermatofibrosarcoma protuberans at the AACR meeting in Philadelphia. Find out here how we’ve identified CDK4 as a therapeutic target in imatinib-resistant DFSP, while establishing a novel laboratory model for this rare cutaneous sarcoma.
Epithelioid fibrous histiocytoma is an ALK-rearranged neoplasm !
This nice study led by Leona Doyle and Jason Hornick demonstrates that epithelioid FH is yet another ALK-rearranged neoplasm (!), providing interesting insights regarding epithelioid FH biology, nosology and diagnostics. Read the full story in Modern Pathology (Epub on April 10).
Novel FGFR1 gene fusion in Phosphaturic Mesenchymal Tumor
Cher-wei Liang and JC Lee, friends and colleagues from Taipei, led this study that identifies recurrent FN1-FGFR1 gene fusions in phosphaturic mesenchymal tumor, a rare neoplastic process that induces osteomalacia by secreting factors such as FGF23. Published in March 2015 in The Journal of Pathology.
New website!
Comment in Nature Reviews Cancer
Food for thought! A little commentary on the potential of studying the frequently overlooked but interesting biology of benign tumors. Take a look here.
New publication in The International Journal of Biochemistry & Cell Biology!
Timely review on Biologically important refinements in subclassification of round cell sarcomas. Check it out here.
New publication in Nature Genetics!
A fantastic new publication from Jonathan Fletcher’s lab just came out in Nature Genetics. Dystrophin is a Tumor Supressor in Myogenic Sarcomas. Check it out!